Serum levels of interleukin-6 type cytokines and soluble interleukin-6 receptor in patients with rheumatoid arthritis
نویسندگان
چکیده
منابع مشابه
Serum levels of interleukin-6 type cytokines and soluble interleukin-6 receptor in patients with rheumatoid arthritis.
We investigated the serum concentrations of interleukin-6 (IL-6) and two IL-6 family of cytokines (leukaemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) as well as IL-6 soluble receptor (sIL-6R) using an enzyme-linked immunosorbent assay (ELISA) in 66 patients with rheumatoid arthritis (RA) and 24 healthy controls. We examined a possible association between the serum levels o...
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By using a sandwich ELISA, soluble human IL-6 receptor (sIL-6 R) levels were measured in the sera of 20 healthy children and of 25 patients with systemic juvenile rheumatoid arthritis (JRA). In patients with systemic JRA, serum sIL-6 R levels (114.6 +/- 37.7 ng/ml) were significantly lower (P < 0.01) than those of healthy children (161.2 +/- 45.5 ng/ml). Serum sIL-6 R levels were negatively cor...
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Background: Rheumatoid arthritis (RA) is a multifactorial autoimmune disease with unidentified etiology. We hypothesized that T cell activation in the rheumatoid synovium might be responsible for the induction of increased expression of soluble interleukin 2 receptor (sIL2R). Objectives: To evaluate in RA whether T cell activation, as reflected by levels of sIL2R was associated with the disease...
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متن کاملInterleukin 6 and Rheumatoid Arthritis
Interleukin-6 (IL-6) is a representative cytokine featuring pleiotropic activity and redundancy. A transient synthesis of IL-6 contributes to host defense against infectious agents and tissue injuries by inducing acute phase reactions and immunological and hematopoietic responses. However, uncontrolled persistent production of IL-6 may lead to the development of several immune-mediated diseases...
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ژورنال
عنوان ژورنال: Mediators of Inflammation
سال: 1998
ISSN: 0962-9351,1466-1861
DOI: 10.1080/09629359890875